Alzheimer Research News
The Alzheimer Research Forum, a dynamic online scientific knowledge base, reports on the latest Alzheimer's scientific research and develops databases of genes, scientific articles, animal models, antibodies, medications, grants, research jobs, and more.
Scientists have made strides turning stem cells into motor neurons, but a motor neuron is useful only when it innervates a muscle...
Ryan Watts of Genentech is the founding research scientist on the clinical trial collaboration with the Alzheimer’s Prevention Initiative...
Francis Collins announced that $16 million of federal funds would go toward the first-ever therapeutic prevention trial in cognitively healthy people...
When the DIAN convened its Pharma Consortium, its scientists intended to brief the Food and Drug Administration on how far DIAN’s work has advanced to date...
Can your state of mind affect your risk of getting Alzheimer’s disease? Perhaps so...
The Dominantly Inherited Alzheimer Network Pharma Consortium met in Washington, D.C., to exchange the latest information on DIAN’s preparation for therapeutic trials...
With statins doing wonders for Alzheimer’s mice and apolipoprotein E as the top risk gene, links between cholesterol and Alzheimer’s presumably run deep...
Deep-brain stimulation (DBS) has become widely used for the treatment of Parkinson's disease, and researchers are now hoping to use it for other diseases, including AD...
Researchers report that they programmed a robot arm to slide a pipette through tissue, checking for cells near its tip along the way until it finds one to patch and analyze...
Results of a multicenter Phase 3 autopsy trial suggest the PET tracer florbetaben accurately images plaques and may prove useful for diagnosis of Alzheimer’s disease...
Identifying injuries that might lead to chronic traumatic encephalopathy or other neurodegenerative pathologies, and then treating those injuries, are two major challenges...
Injury to the brain, even what might be considered mild, can have devastating consequences on brain physiology...
Research suggests that the hippocampus goes into overdrive in people who may be on the path to Alzheimer's disease...
Although a growing number of studies suggest that exercise can perhaps ward off dementia, only a couple of those studies have included objective measures of activity...
There is now convincing evidence that traumatic brain injury can lead to pathologies, including deposition of Aβ, that are akin to those seen in certain neurodegenerative disorders...
Keeping muscles strong and active in a mouse model of ALS allows the animals to perform better in the face of dwindling motor neuron input, but ultimately cannot slow their demise...
Increasingly, sports-related head injuries, which can lead to chronic traumatic encephalopathy, are seen as a major public health concern...
Researchers report that a highly neurotoxic, pyroglutamylated form of Aβ acts as a “bad seed,” corrupting normal peptide...
In a potential victory for AD research, a federal court ruling knocked the wind out of patent litigation that has long scuttled distribution of APPswe mice...
Over the last decade, scientists have realized that brain injury can precipitate similar pathologies to those found in people with neurodegenerative conditions...
Epilepsy-like seizures—though they may be hard to detect—turn up in some people with AD and in transgenic mouse models of the disease...
Christopher Shaw received the Sheila Essey Award 24 April at the American Academy of Neurology (AAN) meeting in New Orleans, Louisiana...
If there is one thing motor neurons cannot handle, it seems to be perturbations to their RNA machinery...
The burgeoning proliferation in glia during neuroinflammation could indicate disease course and the efficacy of potential medicines...
Synapses go haywire long before people with Alzheimer’s disease suspect problems with their memory, but what primes neurons for synaptic dysfunction in the first place?...
A few micrograms of pure, synthetic, aggregated α-synuclein is all it takes to corrupt normal protein in the brain...
Yesterday, Health and Human Services (HHS) Secretary Kathleen Sebelius gave a status report on the National Alzheimer's Plan...
Increasingly, upcoming trials for Alzheimer's therapeutics will target prevention—seeing whether drugs can stave off the disease before it takes hold...
Scientists have begun hunting for genes influencing brain features that associate with disease risk but can be measured years before symptoms crop up...
Aging trumps everything as a risk factor for sporadic AD, but after decades of study, researchers are still unclear why. One theory blames accumulating oxidative damage...
The total tau to amyloid-β42 ratio from cerebrospinal fluid reliably distinguishes Alzheimer’s disease from frontotemporal degeneration...
Janssen Alzheimer Immunotherapy and Pfizer, Inc., together with the Geoffrey Beene Gives Back® Alzheimer’s Initiative, announced five finalists for the Alzheimer's Challenge 2012...
Floundering motor neurons rely on a support network for help, and they send out a distress call to astroglia in the form of angiogenin...
What do prion-like proteins do when not converting neighbors to dangerous conformations? One of them helps stabilize functional protein complexes...
Because neurons are postmitotic—unable to divide or regenerate once formed in the brain—scientists long believed that neurodevelopmental diseases were irreversible...